LCM™ and Air Quality (Radon)

Highlights:

  • Radon is the second leading cause of lung cancer in non-smokers, with additional significant HR/OR/RR of childhood leukemias. Environmental monitoring of radon across US homes is limited. This application note generates the first known dataset of radon-exposure tethered to robust multiomics biomarker assessments via TimepointDx LCM™ for inhabitants (families) of single-family homes within the US.
  • TimepointDx LCM™ for in-home radon detection is the first real-time, high-sensitivity molecular characterization of environmental exposure (radon) via longitudinal capillary multiomics over multiple timepoints for families living in radon-afflicted homes.
  • Real-time radon counts (30 counts per hour in pCi/L with a dynamic range of 0.2-99.9 pCi/L) were collected in real-time via mini pulsed ionization chambers placed inside of homes across the US. This data demonstrated fluctuation of radon counts over time (daily counts captured over 1+ years).
  • TimepointDx LCM™ was implemented over bi-weekly and monthly cadence alongside real-time radon monitoring to capture LCM™ biomarker data.
  • Additional assessments for SDoH metrics and ePROs were captured, highlighting health equity challenges and environmental justice issues across the US with regard to radon exposure.
  • This is the first longitudinal capillary multiomics dataset to robustly capture biomarker, geographical, environmental, and patient-reported feedback within radon-afflicted homes in the US.

See White Paper for Details.

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